SSRI
selective serotonin reuptake inhibitor: any of a class of antidepressants that are thought to act by blocking the reuptake of serotonin into serotonin-containing presynaptic neurons in the central nervous system (see also serotonin agonist). The SSRIs have demonstrated efficacy in the treatment of not only depression but also panic disorder and obsessive-compulsive disorder as well as eating disorders and premenstrual dysphoric disorder. However, the relationship of the reuptake mechanism to the therapeutic qualities of these agents has not been clearly elucidated. SSRIs also block the activity of certain subtypes of serotonin autoreceptors, and this may also be associated with their therapeutic effects. SSRIs have fewer adverse effects than the tricyclic antidepressants and the monoamine oxidase inhibitors, but common side effects include nausea, headache, anxiety, and tremor, and some patients may
experience sexual dysfunction. SSRIs include fluoxetine, paroxetine, sertraline, citalopram, and fluvoxamine. Also called SRI (serotonin reuptake inhibitor).