clomipramine
n. a tricyclic antidepressant drug used for the treatment of obsessive-compulsive disorder (OCD) as well as depression and panic disorder. Clomipramine is a more potent inhibitor of serotonin reuptake than other tricyclic antidepressants, and its active metabolite, desmethylclomipramine, inhibits norepinephrine reuptake; it thus is classified as a mixed serotonin–norepinephrine reuptake inhibitor. Because of its tricyclic structure, it has the same adverse side effects and toxicity as other tricyclic antidepressants, and it has been largely supplanted by the SSRIs, one of which—fluvoxamine—is also used for the treatment of OCD. U.S. trade name: Anafranil.