entorhinal cortex

a region of cerebral cortex in the ventromedial portion of the temporal lobe. It has reciprocal connections with the hippocampal formation and various other cortical and subcortical structures and is an integral component of the medial temporal lobe memory system. It is also involved in spatial navigation. Lesions in this area are used to study neural plasticity and working memory; they are also seen in temporal lobe epilepsy and the early stages of Alzheimer’s disease.