LAAM
L-alpha-acetyl-methadol: a long-acting opioid agonist that is a chemical analog of methadone. A strong agonist at the mu opioid receptor, it can be used in oral form in the management of opioid dependence because of its ability to suppress physical withdrawal symptoms and block the reinforcing effects of opioids. It has a longer half-life (about 72 hours) than methadone and therefore needs to be taken less frequently, a major advantage over methadone (which is taken daily). However, due to its possible adverse effects on heart rate and its interactions with other drugs, LAAM is no longer manufactured in the United States, Europe, and Canada.