glutamate hypothesis

the theory that decreased activity of the excitatory neurotransmitter glutamate is responsible for the clinical expression of schizophrenia. The hypothesis, supported by a number of studies, developed from observations that administration of NMDA receptor antagonists, such as PCP (phencyclidine) and ketamine, produce psychotic symptoms in humans. See also dopamine hypothesis.

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Psychology term of the day

February 25th 2025

essential tremor

trembling of the hands, head, or voice that appears to be hereditary. It is the most common type of movement disorder and is thought to be a benign condition, although its etiology and neurological substrates remain unclear. Also called familial tremor.