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glutamate hypothesis

the theory that decreased activity of the excitatory neurotransmitter glutamate is responsible for the clinical expression of schizophrenia. The hypothesis, supported by a number of studies, developed from observations that administration of NMDA receptor antagonists, such as PCP (phencyclidine) and ketamine, produce psychotic symptoms in humans. See also dopamine hypothesis.

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Psychology term of the day

May 30th 2024

behaviorally anchored rating scale (BARS)

Sorry, "behaviorally-anchored-rating-scale-bars" is not in the Dictionary of Psychology. Please report to APA if you believe this is an error.