dopamine hypothesis

the influential theory that schizophrenia is caused by an excess of dopamine in the brain, due either to an overproduction of dopamine or a deficiency of the enzyme needed to convert dopamine to norepinephrine (adrenaline). There is some supporting pharmacological and biochemical evidence for this hypothesis, and it is still widely discussed and promoted, particularly in a revised form that postulates the involvement in schizophrenia of both an increased mesolimbic and a decreased prefrontal dopaminergic activity. See also glutamate hypothesis.

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Psychology term of the day

February 25th 2025

psychomimic syndrome

a condition in which an individual who lacks physical evidence of an illness develops symptoms of an illness experienced by another person, who may have died of the disorder. The symptoms usually occur around the anniversary of the death of the other person. See also anniversary reaction.