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gastroduodenal ulceration

ulceration of the mucosa lining of the stomach and duodenum caused by hydrochloric acid and the digestive enzyme pepsin, which are secreted by the stomach. Although in some cases gastroduodenal ulceration is due to secretion of excess acid, in many others secretion is normal but the mucosa is more susceptible to the acid’s effects. Factors implicated in this increased susceptibility include infection with Helicobacter pylori bacteria and long-term use of NSAIDs (nonsteroidal anti-inflammatory drugs; e.g., aspirin, ibuprofen); there may also be a familial or genetic factor. Gastric (stomach) ulcers tend to develop later in life and are less likely to be associated with increased acid secretion than are duodenal ulcers. See also dyspepsia; ulcer.

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Psychology term of the day

May 25th 2024



n. the point at which either axis of a graph is intersected by a line plotted on the graph. For example, it is the value of y when x = 0 in an equation of the form y = a + bx, or the value of x where a regression line crosses the y-axis. See also x-intercept; y-intercept.