1. estrangement from others, resulting in the absence of close or friendly relationships with people in one’s social group (e.g., family, workplace, community).

2. a deep-seated sense of dissatisfaction with one’s personal existence and a lack of trust in one’s social or physical environment or in oneself.

3. estrangement from one’s own customary or expected ways of functioning.

4. the experience of being separated from reality or isolated from one’s thoughts, feelings, or physical being, as in derealization and depersonalization. —alienated adj.