sibutramine
n. an appetite suppressant used for the management of obesity. Sibutramine acts on the central nervous system to inhibit the reuptake of the neurotransmitter epinephrine and, to a lesser extent, serotonin and dopamine. Sibutramine may raise blood pressure, and because of its ability to release monoamines, it should not be used in conjunction with monoamine oxidase inhibitors. Like other appetite suppressants, it is effective only in conjunction with dietary restriction. Due to concerns about serious adverse effects, it has been removed from the market in many countries, including the United States. Former U.S. trade name: Meridia.