satiety
n. the state of being fully satisfied to or beyond capacity, as, for instance, when hunger or thirst have been fully assuaged, which inhibits any desire to eat or drink more. Ingested food, for example, provides two signals of inhibition, one reflecting the bulk of a consumed meal and associated with gastric distension and the other reflecting the chemical content of the meal and associated with numerous peptides, hormones, and cytokines in the intestines and liver (notably including cholecystokinin, ghrelin, and leptin). Satiety signals from the gastrointestinal tract travel via different branches of the vagus nerve to act through the arcuate nucleus of the hypothalamus and the solitary nucleus of the brainstem, where neuronal networks mediating food intake and eating behavior are activated.