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olfaction

n. the sense of smell, involving stimulation of receptor cells in the olfactory epithelium (located in the nasal passages) by airborne volatile substances called odorants. Specifically, olfactory receptors extend numerous cilia into the olfactory mucosa in the roof of the nasal cavity; these cilia, together with villi of supporting tissue cells, form a layer of hairlike projections. Molecules of odorants are absorbed into nasal mucus and carried to the olfactory epithelium, where they stimulate the receptor sites of the cilia. The olfactory receptors carry impulses in axonal bundles through tiny holes in the cribriform plate, the bony layer separating the base of the skull from the nasal cavity. On the top surface of the cribriform plate rests the olfactory bulb, which receives the impulses and sends them on to the periamygdaloid cortex. —olfactory adj.

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Psychology term of the day

September 8th 2024

NMDA receptor

NMDA receptor

a type of glutamate receptor that binds NMDA as well as glutamate. NMDA receptors are coupled to ligand-gated ion channels and are also voltage-sensitive, which enables them to participate in a variety of information-processing operations at synapses where glutamate is the neurotransmitter. The drugs of abuse ketamine and PCP are antagonists at NMDA receptors, preventing the influx of calcium ions at calcium channels, which may cause the hallucinogenic effects of these drugs. Excessive flow of calcium ions into the presynaptic neuron via the NMDA receptor is thought to contribute to glutamate toxicity. A hypothesis on the etiology of schizophrenia involves dysfunction of the NMDA glutamate receptor (see glutamate hypothesis). Compare AMPA receptor.