nomifensine

n. an antidepressant that is structurally different from any in current use. It blocks the synaptic reuptake of norepinephine and dopamine but not of serotonin. Due to severe, sometimes fatal, drug reactions, including acute hemolytic anemia, it was withdrawn worldwide in 1986. However, it is still used in research in laboratory animals. Former U.S. trade name: Merital.

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Psychology term of the day

January 11th 2025

dose–response relationship

a principle relating the potency of a drug to the efficacy of that drug in affecting a target symptom or organ system. Potency refers to the amount of a drug necessary to produce the desired effect; efficacy refers to the drug’s ability to act at a target receptor or organ to produce the desired effect. Dose–response curves may be graded, suggesting a continuous relationship between dose and effect, or quantal, wherein the desired effect is an either–or phenomenon, such as prevention of arrhythmias. There is considerable variability among individuals in response to a given dose of a particular drug.