nephrogenic diabetes insipidus

a form of diabetes in which the kidneys are unable to produce a normal concentration of urine because the kidney tubules do not respond to vasopressin produced by the pituitary gland. Individuals with this disorder drink enormous amounts of water and excrete large volumes of dilute urine. The disorder can be critical in infants, who cannot communicate their thirst and therefore suffer water depletion, which may lead to brain damage and intellectual disability before the cause can be diagnosed.

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Psychology term of the day

December 18th 2024

isoniazid

n. a drug of choice for the treatment of tuberculosis. Use of the drug can cause a form of neuritis by blocking the function of pyridoxine (vitamin B₆) in metabolizing glutamic acid to form the neurotransmitter gamma-aminobutyric acid. Isoniazid is structurally related to a known monoamine oxidase inhibitor (MAOI), iproniazid, and was reputed to have some antidepressant activity, although it is not clinically used in this role and is not an MAOI. Also called isonicotinic acid hydrazide (INH).