1. a form of schizophrenia in which both negative and positive symptoms are prominent or neither is prominent. [defined in 1982 by U.S. psychiatrists Nancy C. Andreasen and Scott A. Olsen]

2. historically, a form of schizophrenia that is manifested by symptoms of two or more of the four major types of schizophrenia described by Emil Kraepelin and Eugen Bleuler: simple, paranoid, catatonic, and hebephrenic (disorganized).