n. an amine hormone, produced mainly by the pineal gland as a metabolic product of the neurotransmitter serotonin, that helps to regulate seasonal changes in physiology and may also influence puberty. It is implicated in the initiation of sleep and in the regulation of the sleep–wake cycle. Melatonin has been investigated in clinical studies as a hypnotic and for the management of circadian rhythm sleep disorders. Although these studies are as yet inconclusive, melatonin is widely available as an over-the-counter medication.