a disorder of infants and children marked by weakness and overgrowth of muscles. It is associated with congenital hypothyroidism and intellectual disability in some cases. Also called Debré–Sémélaigne syndrome. [reported in 1892 by Swiss surgeon Emil Theodor Kocher (1841–1917) and in the 1930s by French pediatricians Robert Debré (1882–1978) and Georges Sémélaigne]