ketoconazole

n. an antifungal agent that has been suggested as a treatment for depression resistant to conventional drugs, due to its ability to inhibit the biosynthesis of steroids. No large-scale clinical data support this. Ketoconazole is a potent inhibitor of numerous cytochrome P450 enzymes (particularly CYP3A4) and has significant interactions with psychotropic drugs that utilize this metabolic path. Its numerous interactions and propensity to cause liver damage limit its use. U.S. trade name: Nizoral.

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Psychology term of the day

January 18th 2025

consistent missing

in parapsychology experiments using Zener cards or similar targets, the phenomenon in which a participant’s “calls,” or guesses, are consistently wrong or significantly below chance expectations. Some people attribute such systematic failure to processing error or a conscious or nonconscious reluctance to confirm psychic ability. See also psi-missing.