1. a technique in behavior therapy that aims to replace an undesired response (e.g., anxiety) with a desired one by counterconditioning. It relies on the gradual substitution of a response that is incompatible with the original one and is potent enough to neutralize the anxiety-evoking power of the stimulus. See also systematic desensitization. [devised by Joseph Wolpe]

2. in neuroscience, the inhibition of one spinal reflex when another is elicited. [proposed by Charles Scott Sherrington]

3. a neural mechanism that prevents opposing muscles from contracting at the same time.

4. the inability to recall two associated ideas or items because of their interference with each other.