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gracile tubercle

an elongated swelling on the upper end of the gracile fasciculus in the medulla oblongata. The tubercle contains the nucleus gracilis, which receives dorsal root fibers from sensory receptors in the leg. Also called clava.

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Psychology term of the day

May 26th 2024

GABAA receptor

GABAA receptor

one of the two main types of receptor protein that bind the neurotransmitter gamma-aminobutyric acid (GABA), the other being the GABAB receptorgabab-receptor. It is located at most synapses of most neurons that use GABA as a neurotransmitter. The predominant inhibitory receptor in the central nervous system, it functions as a chloride channel (see ion channel). GABA agonists, such as the barbiturates and benzodiazepines, enhance the binding of GABA to GABAA receptors, allowing for increased conductance of chloride through the ion channel and thereby hyperpolarizing the neuron and inhibiting its activity. GABA antagonists, such as bicuculline and picrotoxin, block the inhibitory effects of GABA at this receptor. Many other substances, including alcohol (ethanol), are thought to exert at least part of their effect via interaction at the GABAA receptor.