1. discontent with the physical or social aspects of one’s own sex.

2. in DSM–5, a diagnostic class that replaces gender identity disorder and shifts clinical emphasis from cross-gender identification itself to a focus on the possible distress arising from a sense of mismatch, or incongruence, that one may have about one’s experienced gender versus one’s assigned gender. Diagnostic criteria for gender dysphoria in children include significant distress or impairment due to marked gender incongruence, such as a strong desire to be—or a belief that one is—the other gender, preference for the toys, games, roles, and activities stereotypically associated with the other gender, and a strong dislike of one’s sexual anatomy. In adults, the manifestations of gender dysphoria may include a strong desire to replace one’s physical sex characteristics with those of the other gender (see sex reassignment), the belief that one has the emotions of the other gender, and a desire to be treated as the other gender or recognized as having an alternative gender identity.