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GABA antagonist

a substance that exerts an antagonistic (inhibitive) effect at gamma-aminobutyric acid (GABA) receptor sites (see GABAA receptorgabaa-receptor; GABAB receptorgabab-receptor) or on the action of GABA. Like GABA agonists, GABA antagonists can be direct or indirect. Direct GABA antagonists block the GABA receptor; the best known of these is bicuculline, which acts as a competitive antagonist for GABA at its receptor site. Indirect GABA antagonists include picrotoxin, which is a noncompetitive antagonist at the GABAA receptor complex and blocks the effects of GABA on the receptor complex.

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Psychology term of the day

May 26th 2024

tranquilizer

tranquilizer

n. a drug that is used to reduce physiological and subjective symptoms of anxiety. In the past, distinctions were made between so-called major tranquilizers (antipsychotics) and minor tranquilizers (anxiolytics; e.g., benzodiazepines).