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epigenetics

n. the study of heritable chemical modifications to DNA that alter gene activity without changing nucleotide sequence. Such modifications instead typically involve the attachment of additional material to the DNA molecule itself (DNA methylation) or the structural alteration of its associated proteins (chromatin remodeling), which disrupt the normal development and functioning of cells by influencing gene activation, deactivation, transcription, and so forth. Epigenetic mechanisms have been proposed as the means by which environmental and psychosocial factors such as toxins and early childhood experiences interact with physiology: They affect neural function through changes in gene expression that lead to individual differences in cognition and behavior (e.g., learning, memory, aggression, affect). Research also suggests that some epigenetic changes of an individual can be passed down to more than one generation of descendants. Additionally, epigenetic abnormalities have been linked to the etiology of many diseases and mental disorders, including autoimmune disturbances, cancer, heart disease, anxiety, autism, depression, intellectual disability, schizophrenia, and substance abuse.

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Psychology term of the day

May 9th 2024

best fit

best fit

the theoretical pattern that best accounts for the relationships among variables in a data set. For example, a regression equation having the best fit to sample data is the one that minimizes differences between observed and predicted values. On a scatterplot, a line of best fit provides a visual depiction of this pattern, allowing extrapolation to values not part of the original data set. It is important to note that the best-fitting pattern is not necessarily the one that generated the observed data, as other patterns not considered may provide a superior fit.