divalproex sodium
an anticonvulsant drug, derived from valproic acid, originally used in the treatment of absence seizures and now used primarily for the stabilization of mania and for prophylaxis in individuals with bipolar disorder. It has also been used in the treatment of various other conditions, including autism, migrainous neuralgia and other forms of head pain, other chronic pain syndromes, and mood symptoms associated with borderline personality disorder. Liver damage and reduction in blood platelets (thrombocytopenia) may occur with use of the drug, so blood count and liver function should be monitored, particularly in the early course of treatment and particularly in children, as most fatalities due to liver failure have occurred in children. Because of its possible association with neural tube defects, divalproex sodium should not be prescribed during pregnancy. The drug has significant interactions with antidepressants, antipsychotics, anxiolytics,
and numerous other classes of medication. U.S. trade name: Depakote.