1. the withdrawal symptoms, usually dominated by feelings of severe depression, that occur following a lengthy period of amphetamine intoxication. The user may sleep for several days more or less continuously, displaying signs of exhaustion and irritation during waking periods. See amphetamine withdrawal.

2. the period following the “rush” or “high” produced by intravenous cocaine administration. As feelings of euphoria wear off, they are replaced by irritability, depression, and anxiety, as well as strong craving for another dose. See cocaine withdrawal.