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agranulocytosis

n. a decline in the number of certain white blood cells (neutrophils), typically as a result of an immune reaction to a drug or other chemical or the toxic effect of this substance on the bone marrow, causing production of white blood cells to fall. Agranulocytosis is diagnosed when the neutrophil count is below 200/mm3 or when the total white-blood-cell count is below 500/mm3. The condition results in suppression of the immune response, rendering individuals vulnerable to opportunistic infections. Psychotropic drugs, such as clozapine and phenothiazine antipsychotics, can induce agranulocytosis.

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Psychology term of the day

December 18th 2024

overmatching

overmatching

n.

1. unnecessary matching: the pairing of research participants on an excessive number of characteristics or on characteristics having little or no potential influence upon the outcome of interest. For example, a researcher investigating a new drug treatment for cancer might create two groups whose members are of the same age and sex, administering the drug to one group and a placebo to the other group. Such group comparability would allow the researcher greater validity in attributing any changes between them to the treatment rather than to sex or age differences. If, however, the researcher were to pair the groups on such additional factors as area of residence and household income, overmatching would be present and likely to mask the true nature of the relationship under investigation and lead to statistical bias, such as by reducing the power and efficiency of analyses.

2. see matching law.