a disorder caused by the deletion of a small piece of chromosome 22, resulting in heart defects, cleft palate or other palate defects, and mild differences in facial features, among other effects. Children with the disorder may also have developmental delays, learning disabilities, attention-deficit/hyperactivity disorder, and autism. As they age, they have an increased risk of developing schizophrenia, depression, anxiety, and bipolar disorder. Because the signs and symptoms are so varied, several conditions (e.g., DiGeorge syndrome, DiGeorge anomaly, velocardiofacial syndrome, Shprintzen syndrome, conotruncal anomaly face syndrome, thymic aplasia syndrome) were once thought to be separate but are now understood to be part of the spectrum of 22q11.2 deletion syndrome.